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# modificationOfTwoSubstratesI -- an example chemical reaction motif

## Description

In this system, two cycles are connected through a joint catalyzing kinase and a joint catalyzing phosphotase [Feliu, Wiuf].

    i1 : modificationOfTwoSubstratesI()

    o1 = S_0+E-->X_1
         X_1-->S_0+E
         X_1-->E+S_1
         S_1+F-->Y_1
         Y_1-->S_1+F
         Y_1-->S_0+F
         E+P_0-->X_2
         X_2-->E+P_0
         X_2-->E+P_1
         F+P_1-->Y_2
         Y_2-->F+P_1
         Y_2-->F+P_0

    o1 : ReactionNetwork

In the motif Modification of Two Different Substrates I, the symbols used in the chemical reactions have the following meaning:

S_i and P_i are substrates with i = 0, 1, 2 phosphorylated sites, E is a kinase and F is a phosphotase, X and Y are the intermediate complexes formed by the enzymes E and F, respectively.

To rename species, use substitute(ReactionNetwork,List).

## Ways to use modificationOfTwoSubstratesI:

- `modificationOfTwoSubstratesI()`

## For the programmer

The object modificationOfTwoSubstratesI is a method function.

The source of this document is in /build/macaulay2-88fgJW/macaulay2-1.25.11+ds/M2/Macaulay2/packages/ReactionNetworks/DocReactionNetworks.m2:410:0.