# About COBBLER

## COBBLER Sequences Displayed by Blocks and Block Maker

COBBLER means COnsensus Biasing By Locally Embedding Residues.

A single sequence is selected from a set of blocks and enriched by replacing the conserved regions delineated by the blocks by consensus residues derived from the blocks. Embedding consensus residues improved performance with readily available single sequence query searching programs, such as BLAST and FASTA, in comprehensive tests.

S. Henikoff and J.G. Henikoff, "Embedding strategies for effective use of information from multiple sequence alignments", Protein Science (1997) 6:698-705. MEDLINE

The COBBLER sequence used with PSI-BLAST has produced excellent results, such as those reported by Thelen, et al for Rad1/PCNA. [Cell article] [PubMed entry]

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